In a study of eight children diagnosed with SCID-X1, doctors collected patients' bone marrow and inserted a corrected copy of their mutated gene (the one that caused them to have little immunity) into the DNA of their blood stem cells. Only boys are affected, due to the faulty gene's pattern of inheritance. The disorder, which is estimated to affect about one in 100,000 newborns, is caused by a mutation in the gene that produces a protein essential for normal immune function. A simple infection like a common cold can be fatal. If left untreated, patients with SCID-X1 - the most common type of SCID - rarely live past their first birthday. Researchers now hope treatment will provide a template to develop new gene therapiesĬhildren with the disorder, called severe combined immunodeficiency or SCID, are born without a functional immune system, meaning they have little to no way of protecting themselves against infection.ĭecades ago, patients with SCID had to be kept inside special plastic chambers, which led to a public fascination with the disease and several 'bubble boy' Hollywood films. Doctors extracted the patients' bone marrow and corrected the genetic defect in their DNA.The babies, born with little virtually no immune protection, now have fully functional immune systems.Infants born with an extremely rare, life-threatening genetic disorder sometimes known as 'bubble boy' disease have been effectively cured thanks to a gene therapy developed by US scientists.
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